Document Type : Original Article


1 Department of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

2 General Dentist

3 Department of Psychiatry, Ibn-e-Sina Psychiatric Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

4 Department of Pediatric Surgery, Akbar Children’s Hospital, Mashhad University of Medical Sciences, Mashhad, Iran



Objective: This study aimed to compare the quality of life of mothers with children born with cleft lip and palate versus mothers with normal children.
Methods & Materials: In this cross-sectional study (descriptive-analytical), 23 mothers of 1 to 3 months old infants with non-syndromic unilateral cleft lip and palate as well as 23 mothers of normal, non-cleft infants as control group were assessed through the standard quality of life SF-36 questionnaire. Data were collected and analyzed using SPSS software (version 16).
Descriptive statistical analysis (mean, percentage, and standard deviation) and analytical statistical test (independent t-test) were used. (P-value <0.05 was considered as significant.)
Results: Present study showed the average quality of life score of mothers of infants with non-syndromic unilateral cleft lip and palate was 64.49. Also, the average quality of life score in the control group was 67.06. The mean quality of life of the two groups did not have any statistically significant differences (P =0.597).
Also, there was no significant difference between the mothers of affected infants and the control group in eight scopes of the questionnaire including general health, physical function, limitation of role play due to physical reasons, limitation of role play for emotional reasons, social function, physical pain, fatigue or cheerfulness, and mental health (P >0.05). Moreover, both groups had a weak level in terms of role limitation due to physical reasons.
Conclusion: According to the results of the present study, both groups did not show a high level of quality of life. Awareness of this issue can guide to providing the necessary social support for all mothers with newborn infants, especially mothers of infants with congenital anomalies such as cleft lip and palate.


Main Subjects

  1. Goodacre T, Swan MC. Cleft lip and palate: current management. Pediatric Child Health. 2008; 6:283–292.
  2. Hodgkinson PD, Brown S, Duncan D, Grant C, McNaughton A, Thomas P, et al.; Management of children with cleft lip and palate: a review describing the application of multidisciplinary team working in this condition based on the
    experiences of a regional cleft lip and palate center in the United Kingdom. Fetal Matern Med Rev. 2005; 16:1–27.
  3. Farronato G, Kairyte L, Giannini L, Galbiati G, Maspero C. How various surgical protocols of the unilateral cleft lip and palate influence the facial growth and possible orthodontic problems? Which is the best timing of lip, palate and alveolus repair? literature review. Stomatologija. 2014;16(2):53-60. PMID: 25209227.
  4. Kramer FJ, Gruber R, Fialka F, Sinikovic B, Hahn W, Schliephake H. Quality of life in school-age children with orofacial clefts and their families. J Craniofac Surg. 2009 Nov;20(6):2061-6. doi: 10.1097/SCS.0b013e3181be8892. PMID: 19881367.
  5. Montazeri A, Goshtasebi A, Vahdaninia M.S. The Short-Form Health Survey (SF-36): translation and validation study of the Iranian version. Payesh. 2006; 5 (1):49-56.
  6. Motamed N, Ayatollahi AR, Zare N, SadeghiHassanabadi A. Validity and reliability of the Persian translation of the SF-36 version 2 questionnaire. East Mediterr Health J. 2005 May;11(3):349-57. PMID: 16602453.
  7. Hupp JR, Ellis E, Tucker MR. Contemporary oral and maxillofacial surgery. St. Louis: Mosby Elsevier; 2008. P. 583-604.
  8. Baker SR, Owens J, Stern M, Willmot D. Coping strategies and social support in the family impact of cleft lip and palate and parents' adjustment and psychological distress. Cleft Palate Craniofac J. 2009 May;46(3):229-36. doi: 10.1597/08-075.1. Epub 2008 Aug 20. PMID: 19642758.
  9. Berger ZE, Dalton LJ. Coping with a cleft: psychosocial adjustment of adolescents with a cleft lip and palate and their parents. Cleft Palate Craniofac J. 2009 Jul;46(4):435-43. doi: 10.1597/08-093.1. PMID: 19642774.
  10. Weigl V, Rudolph M, Eysholdt U, Rosanowski F. Anxiety, depression, and quality of life in mothers of children with cleft lip/palate. Folia Phoniatr Logop. 2005 Jan-Feb;57(1):20-7. doi: 10.1159/000081958. PMID: 15655338.
  11. Naros A, Brocks A, Kluba S, Reinert S, Krimmel M. Health-related quality of life in cleft lip and/or palate patients - A cross-sectional study from preschool age until adolescence. J Craniomaxillofac Surg. 2018 Oct;46(10):1758- 1763. doi: 10.1016/j.jcms.2018.07.004. Epub 2018 Jul 11. PMID: 30054220.
  12. Emeka CI, Adeyemo WL, Ladeinde AL, Butali A. A comparative study of quality of life of families with children born with cleft lip and/or palate before and after surgical treatment. J Korean Assoc Oral Maxillofac Surg. 2017 Aug;43(4):247-255. doi: 10.5125/jkaoms.2017.43.4.247. Epub 2017 Aug 24. PMID: 28875139; PMCID: PMC5583199.
  13. Kramer FJ, Gruber R, Fialka F, Sinikovic B, Schliephake H. Quality of life and family functioning in children with nonsyndromic orofacial clefts at preschool ages. J Craniofac Surg. 2008 May;19(3):580-7. doi: 10.1097/SCS.0b013e31816aaa43. PMID: 18520368.
  14. Schuster M, Kummer P, Eysholdt U, Rosanowski F. Soziale Orientierung der Eltern von Kindern mit Lippen-Kiefer-GaumenSpalten [Social orientation of parents of children with cleft lip and palate]. HNO. 2003 Jun;51(6):507-12. German. doi: 10.1007/s00106- 003-0843-9. Epub 2003 May 13. PMID: 12835850.
  15. Awoyale T, Onajole AT, Ogunnowo BE, Adeyemo WL, Wanyonyi KL, Butali A. Quality of life of family caregivers of children with orofacial clefts in Nigeria: a mixed-method study. Oral Dis. 2016 Mar;22(2):116-22. doi: 10.1111/odi.12379. Epub 2015 Dec 18. PMID: 26456150; PMCID: PMC4744119.