Cleft lip and palate is among the most common congenital anomalies of the head and neck region. Treatment of cleft lip and palate is challenging and requires the cooperation of various medical teams. A 15 year-old patient with a cleft lip and palate presented to the Department of Orthodontics at ShahidBeheshti University, School of Dentistry complaining of unattractive appearance. The patient had unilateral cleft lip and palate and congenitally missing maxillary left lateral incisor and mentioned a history of surgical repair of the cleft in childhood. He had a concave profile, -5mm overjet, -5mm Wits appraisal and abnormal eruption path of teeth especially for the maxillary left central incisor. The patientunderwent orthodontic treatment without orthognathic surgery. Post-treatment records showed excellent results in terms of occlusion and facial balance and harmony.