1 Professor Dentofacial Deformities Research Center, Research Institute of Dental Sciences and School of Dentistry, Shahid Beheshti University of Medical Sciences

2 Postgraduate Student of Orthodontics, DDS, Dental Research Center, Research institute of Dental Sciences of Shahid Beheshti University of Medical Sciences, Tehran,Iran

3 Dentist,Tehran, Iran



Background and aim: Orthodontic tooth movement requires remodeling of periodontal tissues, especially alveolar bone. A major objective of investigators is to achieve maximum tooth movement with minimal root damage. The aim of this study is to determine if the rate and amount of orthodontic tooth movement in a sample of rats could be enhanced by the injection of a vitamin D metabolite and Prostaglandin E2.
Materials and Methods: Thirty-Two male Wistar rats were randomly divided into 4 groups of eight rats each: 
1- 1.5 IU/ml vitamin D was injected into the thigh muscle after installation the orthodontic appliance in first group (Vit D group)
2- 0.1 ml of 1 mg/ml PGE2 was injected submucosally in the second group (PGE2 group).
3- In the third group, 1.5 IU/ml vitamin D and 0.1 ml of 1 mg/ml PGE2 was injected submucosally (Vit D+ PGE2).
4- Distilled water (0.1 ml) was used in control group .In order to calculate the tooth movement; the distance between the upper right first and second molars was measured.
Results: All groups have a significant difference with control group (p<0.05). The most mean OTM was observed in the Vit D+PGE2 group (Mean = 0.702± 0.04897mm) that was significantly higher than the Vit D, PGE2 and control groups (P< 0.05). A significant difference (P< 0.05) in root resorption was observed between the PGE2 (0.0192 ±0.000675 mm2) and the other groups.
Conclusion: In order to achieve a decrease in root resorption and an increase in OTM, the combination Vit D+PGE2 is useful and there is a synergism effect with Vit D and PGE2.