Document Type : Original Article


1 Associate Professor, Department of Orthodontics, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran

2 Postgraduate Student, Department of Orthodontics, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran

3 Assistant Professor, Dental Research Center and Dental Implant Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

4 Dentist, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran

5 Associate Professor, Department of Biostatistics, School of Public Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran


Aim: Formation of white spot lesions (WSL) subsequent to orthodontic treatment is a cosmetic concern. This research assessed the effects of bioactive-glass toothpaste on remineralization of orthodontic white spot lesions.
Methods: Orthodontic brackets were boned to seventy extracted premolars. Then they were submersed in a demineralization solution (pH=4.52) at 37°C for 96 hours, which led to the formation of artificial caries lesions on enamel. Occlusal brackets were assigned to the treatment group, whereas gingival brackets were assigned to the control group.
Specimens were allocated to one of two groups: group 1) toothpaste containing sodium fluoride (1,450 ppm), group 2) toothpaste containing bioactive glass (5%). The samples underwent a 14-day remineralization/demineralzation cycle consisting of a twice-daily 30-minute submersion in a demineralizing solution (pH=4.52, 37°C) followed by a five-minute toothpaste treatment for the occlusal of the brackets. Each sample was analyzed using a polarized microscope, and AutoCAD 2007 was used to quantify the mineralization depth and area. Using SPSS version 23, the independent and paired t-tests were used to assess data statistically.
Results: In terms of both remineralization area and depth, the study's findings revealed a statistically significant difference between the experimental and control groups (p < 0.001). Area and depth differences between the two remineralization methods in the treatment group were also statistically significant (p < 0.001).
Conclusion: Both sodium fluoride and bioactive-glass toothpaste are useful for remineralizing the WSL, while bioactiveglass toothpaste seems to work more effectively than sodium fluoride toothpaste.


Main Subjects

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