Aim: Orthodontists and patients prefer minimal time for orthodontic treatment. The submucosal injection of
platelet-rich plasma (PRP) helps to provide tooth movement without surgery or alveolar bone loss. The
purpose of this research was to assess the rate of space closure using PRP injection with the conventional
Methods: In this preliminary study, 10 patients aged 14-20 years, requiring first premolar extractions in both
arches using MBT technique were included. This was a split-mouth study wherein, on one side (experimental),
space closure was done using a submucosal injection of 0.7 ml PRP, and the other side (control) was subjected
to conventional space closure using an active tie back with a constant force of 200 gm. Statistical analysis was
performed using a paired t-test. P-value <0.05 was set for statistical significance.
Results: The findings of the research showed no significant difference in the rate of space closure between the
case and control groups in the maxilla (P=0.073); however, there was a significant difference between the
experimental and control groupsin the mandible (P=0.04).
Conclusion: Analyzing space closure rate between the control and experimental side showed that PRP
injection did affect the acceleration of space closure in the mandible.